Multi-Functional Linking Agent for Imaging and Therapy

Description:

MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPY

 

Imaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spread throughout the body, a cytotoxic compound can be combined with radioactive label to develop a “theranostic” method to see and treat disease. Tumor-specificity is critical to the success of these approaches and investigators at The University of Texas Health Science Center at Houston have developed a multimodality chelator (MMC) scaffold that allows enhancement of clinically established targeting agents to improve how surgery and therapy are performed.

 

Technology Overview

An interdisciplinary team of investigators in the Institute of Molecular Medicine at The University of Texas Health Science Center at Houston have developed a multimodality chelation (MMC) scaffold that is capable of assembling various targeting agents, fluorophores, and therapeutic agents on a single moiety. Their focus is to add additional imaging and/or therapeutic capabilities to clinically validated imaging agents, and the MMC scaffold allows them to accomplish this while retaining key imaging characteristics of the targeting agent (i.e., affinity, rapid elimination, low non-specific signal). For example, the MMC can be used to link a cancer-targeting peptide with a near-infrared agent so that a specific tumor type could be visualized pre-operatively using a PET/CT scan and intraoperatively using near-infrared imaging systems. Additionally, the modularity of the MMC scaffold enables conversion of a conventional imaging agent into a “theranostic” analog by mounting a therapeutic payload, thus providing a new therapeutic option for patients and a built-in patient selection strategy.

 

Potential Applications

•       Prep-operative PET imaging for surgical planning and fluorescence-guided surgery to improve patient outcomes with a single agent

•       Validation of intraoperative agents through dual-labeling with the MMC scaffold can facilitate translational studies

•       Targeted drug delivery to tumors with highly potent cytotoxics which cannot be used alone

•       Potential to provide new therapeutic options to patients which would not otherwise be indicated

 

Technology Advantages

•       Modular, various payloads can be attached to MMC;

•       Retains bioactivity of targeting agent;

•       Suitable for incorporation into solid-phase synthesis;

•       Compatible with various radionuclides; and

•       Compatible with all relevant bioconjugation techniques

 

Intellectual Property Status:

•       Patent application pending.

•       Portfolio available for licensing.

 

Stage of Development

The investigators have developed multimodality imaging agents and “theranostics” from a standard MMC and have tested these in vivo. Additional in vivo studies are ongoing.

 

Associated Publication

Multimodal chelation platform for near- infrared fluorescence/nuclear imaging; PMID 23214723.

 

 

Image description.  (Left) In vitro characterization of a radiolabeled 5-fluorouricil drug conjugate in cancer cells showed high agent uptake in the absence of blocking agent which was reduced in a dose-dependent manner. (Right) PET/CT image of a tumor-bearing mouse injected with the radiolabeled 5-fluorouricil drug conjugate showing high tumor uptake (arrow) and image contrast. Notice that presence of the chemotherapy agent 5-fluorouracil does not impair the tumor targeting.

 

 

About the Investigator 

Dr. Ali Azhdarinia’s laboratory is at the interface of chemistry and biology and is focused on developing molecules for the visualization and treatment of disease. Using novel chemistry platforms, they have the ability to produce molecules with multiple labels and thus, multiple applications.  The apply fundamental expertise in chemistry, imaging, and drug characterization to develop new classes of molecular imaging agents and focus on translation of discoveries and technologies into the clinic to improve human health. 

 

 

Patent Information:

The preceding is intended to be a non-confidential and limited description of a novel technology created at the University of Texas Health Science Center at Houston (UTHealth). This promotional material is not comprehensive in scope and should not replace company’s diligence in a thorough evaluation of the technology. Please contact the Office of Technology Management for more information regarding this technology.
Category(s):
Diagnostics
Drug Delivery
For Information, Contact:
Christine Flynn
Associate Director, Licensing and New Venture Development
University of Texas Health Science Center At Houston
Christine.Flynn@uth.tmc.edu
Inventors:
Ali Azhdarinia
Keywords:
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