Search Results - Drug+Delivery

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Formulation of HDACi Loaded ß-Cyclodextrin-poly (ß-amino ester) Nanoparticles
Researchers have developed a novel formulation strategy to encapsulate molecules, including but not limited to histone deacetylase inhibitor (HDACi) drugs in nanoparticle networks composed of beta-cyclodextrin-poly(beta-amino esters). Advantages of this system include high loading capacity, increased in vivo tolerability, sustained release, and improved...
Published: 1/15/2020   |   Inventor(s): Rachael Sirianni
Category(s): Drug Delivery, Therapeutics, Oncology
Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payloads...
Published: 10/17/2019   |   Inventor(s): Kyoji Tsuchikama, Yasuaki Anami, Chisato Tsuchikama, Zhiqiang An, Ningyan Zhang
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Multi-Functional Linking Agent for Imaging and Therapy
MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPYImaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spread...
Published: 7/16/2019   |   Inventor(s): Ali Azhdarinia
Category(s): Diagnostics, Drug Delivery
Multistage Nanoparticle Drug Delivery Systems
The Market: The American Cancer Society estimates that in the United States alone, over 1,000,000 people are diagnosed with cancer. Many cancer deaths, specifically from cancers of the colon, breast, rectum, and uterine cervix cancers, could be significantly reduced with earlier detection and improved targeted delivery of chemotherapeutics. The National...
Published: 5/23/2017   |   Inventor(s):  
Category(s): Therapeutics, Drug Delivery
Di-functional Hyaluronic Acid for Tissue Engineering
Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cells...
Published: 4/14/2017   |   Inventor(s): Laura Smith Callahan, Hyun ju Lim
Category(s): Drug Delivery, Research Materials, Therapeutics
Nested Nanoparticles for Site-specific, Sequential Drug Delivery
New nested nanoparticles for drug delivery have been developed at UTHealth to deliver multiple drugs in a site-, time-, and sequence-specific manner. These nanoparticles consist of a drug-containing polymeric core made of PLGA, surrounded by an outer shell of cyclodextrin complexed with a second drug. These two delivery components facilitate dual-release...
Published: 5/24/2016   |   Inventor(s):  
Category(s): Drug Delivery
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