Search Results - Diagnostics

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Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 3/21/2024 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics

TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...

Published: 12/19/2023 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Therapeutics, Oncology, Diagnostics

Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction

The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which...

Published: 8/15/2023 | Inventor(s):

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics, Diagnostics

Directional and Scalable (DISC) Electrode Array

Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field...

Published: 8/15/2023 | Inventor(s): John Seymour, Nitin Tandon

Keywords(s):

Category(s): Medical Devices, Neurology/Neurosurgery, Diagnostics

LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 8/15/2023 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

Monoclonal Antibodies Against Oncostatin M Receptor (OSMR) for Therapeutic and Diagnostic Use

Researchers from UTHealth and The Medical College of Wisconsin have collaborated to reveal the role of OSMR in promoting ovarian cancer cell proliferation and metastasis through activation of STAT3 signaling, as well as illuminated the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment. More particularly, researchers...

Published: 9/27/2023 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Diagnostics, Therapeutics, Biologics, Oncology

Peptides Targeting Chemotherapy-Resistant Metastatic Cancer Cells for Therapeutic and Diagnostic Use

Researchers at UTHealth have identified new molecules that selectively target metastatic cancer cells in mammals both in vitro and in vivo by screening a combinatorial library in a mouse mammary tumor model of spontaneous metastasis, and demonstrated their application as noninvasive imaging probes and vehicles for cytotoxic therapy delivery in preclinical...

Published: 3/26/2024 | Inventor(s): Mikhail Kolonin

Keywords(s):

Category(s): Oncology, Therapeutics, Diagnostics

HER3 specific monoclonal antibodies for diagnosis and therapeutic use

BackgroundHER-3 is a receptor in the tyrosine kinase family that is a key oncogenic protein in breast cancer as well as other cancers. HER-3 is centrally involved in signaling leading to tumor growth and has been implicated in resistance to cancer treatments, making it an attractive target for cancer therapies. Several drugs, including some in clinical...

Published: 8/15/2023 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Therapeutics, Diagnostics

PocketPerio

BackgroundIn 2017, the updated classification of Periodontal and Peri-implant Diseases and Conditions was proposed and recommended for its use by the American Academy of Periodontology and the European Federation of Periodontology. The proposed changes were summarized in 20 articles simultaneously published in the Journal of Periodontology and Journal...

Published: 8/15/2023 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Software

Monoclonal Antibodies targeting EpCAM

AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via...

Published: 8/15/2023 | Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia

Keywords(s):

Category(s): Biologics, Research Materials, Oncology, Diagnostics

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