Search Results - Diagnostics

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Monoclonal Antibodies targeting EpCAM
AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection v...
Published: 10/17/2019   |   Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia
Category(s): Biologics, Research Materials, Oncology, Diagnostics
Multi-Functional Linking Agent for Imaging and Therapy
MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPYImaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spr...
Published: 7/16/2019   |   Inventor(s): Ali Azhdarinia
Category(s): Diagnostics, Drug Delivery
Methods and composition for novel anti-cancer treatments
Background: The Wnt signaling pathway plays essential roles in development and is frequently hyperactivated in cancer cells as a driving mechanism. Nearly 90% of colon cancers, for examples are mutated in this pathway. However, direct targeting of this pathway for cancer drug discovery has been challenging due to receptor redundancy and compl...
Published: 6/26/2019   |   Inventor(s):  
Category(s): Therapeutics, Diagnostics
Methods of X-aptamer generation and compositions thereof
Aptamers are structurally distinct RNA and DNA oligonucleotides (ODNs) that can mimic protein-binding molecules and exhibit high (nM) binding affinity based on their unique secondary three-dimensional structure conformations and not by pair-wise nucleic acid binding. Aptamers can be selected via high-throughput in vitro methods to bind target molec...
Published: 6/26/2019   |   Inventor(s):  
Category(s): Therapeutics, Diagnostics
Compositions and Methods for Long-Term in Vitro Culture Of The Syphilis Spirochete.
Background Syphilis is a multistage sexually transmitted infection of world-wide importance, with an estimated 5.6 million new cases per year. Treponema pallidum, the causative agent of syphilis, was first identified by Schaudinn and Hoffman in 1905, but in the past researchers have been unable to maintain T. pallidum viability or multiplication be...
Published: 2/6/2019   |   Inventor(s): Steven Norris, Diane Edmondson
Category(s): Diagnostics, Research Materials
Genomic DNA Mutation Assays and Uses Thereof
Mutations are the primary cause of genetic disorder and cancer. The ability to detect mutations in the genome holds the key to diagnosis, treatment, and prevention of the disease. Recent developments in novel sequencing technology have made efforts in sequencing hundreds of thousands of human genomes a reality. However, it remains challenging to id...
Published: 6/21/2018   |   Inventor(s):  
Category(s): Diagnostics
Lymphatic Imaging System
Near-Infrared Fluorescence Imaging Using Military-Grade Imaging Technology For Lymphatic DiagnosticsMarket: The visualization of the lymphatic system is essential during the diagnosis and treatment of a multitude of conditions and diseases—locating lymphatic structures, diagnosing and monitoring lymphedema, and detecting metastatic lesions du...
Published: 11/9/2017   |   Inventor(s):  
Category(s): Diagnostics, Medical Devices
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections Dr. Charles Darkoh has identified and developed novel compounds that may reduce or inhibit toxin production and toxin activity, which directly and selectively targets the cause of C. difficile-associated illness. Dr. Darkoh has further developed potential combinati...
Published: 1/28/2016   |   Inventor(s): Charles Darkoh
Category(s): Diagnostics, Therapeutics
SUMO-Specific Protease Nucleotides and Proteins for Diagnosing Hyperpoliferative Diseases
Market: Prostate cancer is the second most common cancer, and second leading cause of cancer death, in American men. The American Cancer Society predicts over 186,000 new diagnoses of prostate cancer, and over 28,000 deaths in the US in 2008. With early detection being key to a better prognosis, a significant number of people are demanding fast...
Published: 11/29/2011   |   Inventor(s):  
Keywords(s): Antibodies, Cancer, Diagnostics, Research tool, Therapeutics
Category(s): Diagnostics, Research Materials, Therapeutics
Immuno-Diagnosis of Lyme Disease
Market: Approximately 20,000 cases of Lyme disease in humans are reported per year in the United States. Lyme disease is the most common tick-borne disease in the US and is also a significant veterinary problem due to a high infection rate of dogs and other domestic animals in endemic regions. The European market is equal to or greater than the ...
Published: 11/3/2011   |   Inventor(s):  
Category(s): Diagnostics, Research Materials
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