Search Results - Diagnostics

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Anti-LILRB5 Monoclonal Antibodies for Therapeutic and Diagnostic Use

Tumor microenvironment (TME) plays a critical role in regulating immune responses to tumors. UTHealth Houston and UTSW researchers discovered certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind to the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and result in bi-directional signaling....

Published: 2/16/2026 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Therapeutics, Oncology

Anti-LILRB1 Monoclonal Antibodies for Therapeutic and Diagnostic Use

LILRB1 expression on myeloid cells regulates both innate and adaptive immune responses. Researchers at UTHealth Houston and UTSW developed novel agonistic anti-LILRB1 monoclonal antibodies (mAbs) for autoimmune and inflammatory disease treatments, and novel antagonistic anti-LILRB1 mAbs for cancer immunotherapies. Background LILRB1, a member of the...

Published: 2/16/2026 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Therapeutics, Oncology

Anti-LAIR1 Monoclonal Antibodies for Therapeutic and Diagnostic Use

Leukocyte associated immunoglobulin like receptor 1 (LAIR1 or CD305) is an immune inhibitory receptor expressing on most immune cell types. Researchers at UTHealth Houston and UTSW generated novel antagonistic anti-LAIR1 monoclonal antibodies (mAbs) that inhibited the activity of immunosuppressive myeloid cells and reactivated T cells from cancer patients...

Published: 2/16/2026 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Therapeutics, Oncology

Anti-LILRB3 Monoclonal Antibodies for Therapeutic and Diagnostic Use

UTHealth Houston and UTSW researchers discovered that LILRB3 stimulates NF-κB signaling and enhances acute myeloid leukemia (AML) cells. They generated a panel of novel anti-LILRB3 monoclonal antibodies (mAbs), which exhibited increasing killing of leukemia cells and promoting cytotoxic T cell activity against tumors. Background Leukocyte immunoglobulin-like...

Published: 2/16/2026 | Inventor(s):

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics

Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 1/15/2026 | Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics, Biologics

TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...

Published: 1/15/2026 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Therapeutics, Diagnostics, Biologics, Neurology/Neurosurgery

Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction

The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which...

Published: 1/15/2026 | Inventor(s):

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics, Diagnostics

Directional and Scalable (DISC) Electrode Array

UTHealth researchers developed a directional and scalable (DISC) electrode array, which achieved directional (stereo) measurements of local field potentials, resulting in up to 3x better signal amplitude, 1.6x higher signal-to-noise (SNR), and 98% decoding accuracy than the average testing results of a tetrode in over 450 stimulation recordings. This...

Published: 1/15/2026 | Inventor(s): John Seymour, Nitin Tandon

Keywords(s):

Category(s): Medical Devices, Neurology/Neurosurgery, Diagnostics

LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 1/15/2026 | Inventor(s): Qingyun (Jim) Liu

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Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

Monoclonal Antibodies Against Oncostatin M Receptor (OSMR) for Therapeutic and Diagnostic Use

Researchers from UTHealth and The Medical College of Wisconsin have collaborated to reveal the role of OSMR in promoting ovarian cancer cell proliferation and metastasis through activation of STAT3 signaling, as well as illuminated the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment. More particularly, researchers...

Published: 1/15/2026 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Diagnostics, Therapeutics, Biologics, Oncology

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