Search Results - Diagnostics

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Directional and Scalable (DISC) Electrode Array
­Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field...
Published: 11/15/2022   |   Inventor(s): John Seymour, Nitin Tandon
Category(s): Medical Devices, Neurology/Neurosurgery, Diagnostics
LGR4 Specific Monoclonal Antibodies and Their Use
­Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...
Published: 6/15/2022   |   Inventor(s): Qingyun (Jim) Liu
Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials
Monoclonal Antibodies Against Oncostatin M Receptor (OSMR) for Therapeutic and Diagnostic Use
­Researchers from UTHealth and The Medical College of Wisconsin have collaborated to reveal the role of OSMR in promoting ovarian cancer cell proliferation and metastasis through activation of STAT3 signaling, as well as illuminated the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment. More particularly, researchers...
Published: 12/16/2021   |   Inventor(s): Zhiqiang An
Category(s): Diagnostics, Therapeutics, Biologics, Oncology
Peptides Targeting Chemotherapy-Resistant Metastatic Cancer Cells for Therapeutic and Diagnostic Use
Researchers at UTHealth have identified new molecules that selectively target metastatic cancer cells in mammals both in vitro and in vivo by screening a combinatorial library in a mouse mammary tumor model of spontaneous metastasis, and demonstrated their application as noninvasive imaging probes and vehicles for cytotoxic therapy delivery in preclinical...
Published: 12/16/2021   |   Inventor(s): Mikhail Kolonin
Category(s): Oncology, Therapeutics, Diagnostics
HER3 specific monoclonal antibodies for diagnosis and therapeutic use
BackgroundHER-3 is a receptor in the tyrosine kinase family that is a key oncogenic protein in breast cancer as well as other cancers. HER-3 is centrally involved in signaling leading to tumor growth and has been implicated in resistance to cancer treatments, making it an attractive target for cancer therapies. Several drugs, including some in clinical...
Published: 1/8/2020   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Category(s): Therapeutics, Diagnostics
BackgroundIn 2017, the updated classification of Periodontal and Peri-implant Diseases and Conditions was proposed and recommended for its use by the American Academy of Periodontology and the European Federation of Periodontology. The proposed changes were summarized in 20 articles simultaneously published in the Journal of Periodontology and Journal...
Published: 11/21/2019   |   Inventor(s):  
Category(s): Diagnostics, Software
Monoclonal Antibodies targeting EpCAM
AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via...
Published: 10/17/2019   |   Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia
Category(s): Biologics, Research Materials, Oncology, Diagnostics
Multi-Functional Linking Agent for Imaging and Therapy
MULTI-FUNCTIONAL LINKING AGENT FOR IMAGING AND THERAPYImaging technologies are uniquely positioned to enhance how localized and metastatic tumors are treated. In cases where surgery is indicated, a novel class of imaging agents which combine radioactive of fluorescent tags can be used to improve tumor visualization in real-time. When cancer has spread...
Published: 7/16/2019   |   Inventor(s): Ali Azhdarinia
Category(s): Diagnostics, Drug Delivery
Methods and composition for novel anti-cancer treatments
Background: The Wnt signaling pathway plays essential roles in development and is frequently hyperactivated in cancer cells as a driving mechanism. Nearly 90% of colon cancers, for examples are mutated in this pathway. However, direct targeting of this pathway for cancer drug discovery has been challenging due to receptor redundancy and complexity....
Published: 6/26/2019   |   Inventor(s): Qingyun (Jim) Liu
Category(s): Therapeutics, Diagnostics
Methods of X-aptamer generation and compositions thereof
Aptamers are structurally distinct RNA and DNA oligonucleotides (ODNs) that can mimic protein-binding molecules and exhibit high (nM) binding affinity based on their unique secondary three-dimensional structure conformations and not by pair-wise nucleic acid binding. Aptamers can be selected via high-throughput in vitro methods to bind target molecules....
Published: 6/26/2019   |   Inventor(s):  
Category(s): Therapeutics, Diagnostics
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