Search Results - john+spudich

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Novel Channelrhodopsins for Optogenetics Gene Therapy
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...
Published: 8/15/2023   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Keywords(s):  
Category(s): Therapeutics, Research Materials
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to treat...
Published: 8/15/2023   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Keywords(s):  
Category(s): Therapeutics, Research Materials
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