Search Results - neurology%2fneurosurgery

4 Results Sort By:
Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier
Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...
Published: 3/21/2024   |   Inventor(s): Zhiqiang An
Keywords(s):  
Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery
Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction
The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which...
Published: 8/15/2023   |   Inventor(s):  
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics, Diagnostics
Directional and Scalable (DISC) Electrode Array
­Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field...
Published: 8/15/2023   |   Inventor(s): John Seymour, Nitin Tandon
Keywords(s):  
Category(s): Medical Devices, Neurology/Neurosurgery, Diagnostics
Systems and methods for network based neurostimulation of cognitive processes
Cognitive processes are brain operations that allow us to perform complex functions that are the very essence of being human—examples include but are not limited to memory, language, control over emotions, resolving conflicting information, reading, making decisions, puzzle solving etc. This invention describes a method and a system that utilizes...
Published: 12/19/2023   |   Inventor(s): Nitin Tandon
Keywords(s):  
Category(s): Medical Devices, Neurology/Neurosurgery
© 2024. All Rights Reserved. Powered by Inteum