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Novel Channelrhodopsins for Optogenetics Gene Therapy
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene therapy using anion ChRs (ACRs) has the potential for treating excessive neuron firing in conditions such as Parkinson’s disease, neuropathic pain and epilepsy, while...
Published: 8/15/2023
|
Inventor(s):
John Spudich
,
Elena G Govorunova
,
Oleg A Sineshchekov
Keywords(s):
Category(s):
Therapeutics
,
Research Materials
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to treat...
Published: 8/15/2023
|
Inventor(s):
John Spudich
,
Elena G Govorunova
,
Oleg A Sineshchekov
Keywords(s):
Category(s):
Therapeutics
,
Research Materials
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