The Technology: Dr. Andrew Bean at the University of Texas Health Science Center at Houston (UTHealth) has developed a monoclonal antibody to Hrs-2. Hrs-2 is a protein that plays a role in the formation and dissolution of protein complexes during vesicular formation. Cellular expression of hrs-2 can be determined via the monoclonal hrs-2 antibody. This antibody will be useful in determining how hrs-2 is regulated and tracking hrs-2 interaction during vesicular trafficking.
Publications:• The cellular and developmental expression of hrs-2 in rat. Eur J Neurosci. 1999 Sep;11(9):3047-63.• Distinct Protein Domains Are Responsible for the Interaction of Hrs-2 with SNAP-25. J Biol Chem. 2000 Jan 28;275(4):2938-42.• SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2001 Sep;281(3):F546-56.• Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15. J Biol Chem. 2000 May 19;275(20):15271-8.• Hrs-2 is an ATPase implicated in calcium-regulated secretion. Nature. 1997 Feb 27;385(6619):826-9.
UTHealth Ref. No.: 2002-0009Inventors: Andrew BeanLicense Available: world-wide; non-exclusive