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Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payloads...
Published: 10/17/2019   |   Inventor(s): Kyoji Tsuchikama, Yasuaki Anami, Chisato Tsuchikama, Zhiqiang An, Ningyan Zhang
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Monoclonal Antibodies targeting EpCAM
AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via...
Published: 10/17/2019   |   Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia
Category(s): Biologics, Research Materials, Oncology, Diagnostics
ebpABC gene deletion mutant TX5608 and E. faecalis strain OG1RF
Endocarditis and biofilm-associated pili (EbpABC) gene deletion of Enterococcus faecalis and WT parent bacteria OG1RF. See published research paper on these bacterial strains: Research paper published:J Clin Invest. 2006 Oct;116(10):2799-807. Endocarditis and biofilm-associated pili of Enterococcus faecalis.Nallapareddy SR, Singh KV, Sillanpää...
Published: 8/16/2019   |   Inventor(s):  
Category(s): Research Materials
Compositions and Methods for Long-Term in Vitro Culture Of The Syphilis Spirochete.
Background Syphilis is a multistage sexually transmitted infection of world-wide importance, with an estimated 5.6 million new cases per year. Treponema pallidum, the causative agent of syphilis, was first identified by Schaudinn and Hoffman in 1905, but in the past researchers have been unable to maintain T. pallidum viability or multiplication beyond...
Published: 2/6/2019   |   Inventor(s):  
Category(s): Diagnostics, Research Materials
Discovery of Allosteric Non-Covalent KRAS Inhibitors
Background: RAS mutations account for >15% of all human tumors, and of these ~85% are due to mutations in a particular RAS gene: KRAS. Currently, there are no approved drugs that can directly act on mutated KRAS to stop its cancer causing activities.Dr. Gorfe at UTHealth has used a structure based computational ligand design approach followed by...
Published: 8/13/2018   |   Inventor(s):  
Category(s): Oncology, Therapeutics, Research Materials
Di-functional Hyaluronic Acid for Tissue Engineering
Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cells...
Published: 4/14/2017   |   Inventor(s): Laura Smith Callahan, Hyun ju Lim
Category(s): Drug Delivery, Research Materials, Therapeutics
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to treat...
Published: 7/13/2016   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Category(s): Therapeutics, Research Materials
Enterotoxigenic Escherichia coli Isolates Identified from Patients with Travelers' Diarrhea
Market: Traveler’s diarrhea is the most common illness affecting travelers, and affects as many as 800 million people a year.  The most common causative agent of traveler’s diarrhea is Enterotoxigenic E. coli. Toxins secreted by these bacteria result in severe watery diarrhea. The Technology: Researchers at the University of Texas Health...
Published: 6/24/2014   |   Inventor(s):  
Category(s): Research Materials
Red and Blue Shifted Channelrhodopsins
Channelrhodopsins (ChRs) are a type of optogenetic tool that have enabled targeted light-activation of neuron firing in tissue culture and in living organisms. Dr. John Spudich at the University of Texas Health Science Center at Houston has characterized several ChRs whose properties make them particularly useful for photocontrol of neuron firing, including...
Published: 6/15/2012   |   Inventor(s):  
Category(s): Research Materials
Anti-STAM Monoclonal Antibodies
The Technology: Dr. Andrew Bean at the University of Texas Health Science Center at Houston, has developed a monoclonal antibody to STAM. STAM is a protein that plays a role in the movement of proteins into lysosome for degradation. Cellular expression of STAM can be determined using this monoclonal antibody, therefore this antibody will be...
Published: 1/5/2012   |   Inventor(s):  
Category(s): Research Materials
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