Antipeptide Antibodies which Recognize Specific Somatostatin Receptor Subtypes

Antipeptide Antibodies That Recognize Specific Somatostatin Receptor Subtypes

The Technology: This patent covers:
1. A method for developing somatostatin receptor subtype specific antibodies.
2. Antibodies developed using this method to identify somatostatin receptor subtypes belonging to the seven transmembrane domain receptor family.
3. The use of these antibodies, alone or in kit form, to identify somatostatin receptors in tissues or protein extracts.

The utility of the patented technology is founded upon its ability to selectively identify somatostatin receptor subtypes and thus will be of great value, but not limited to, the fields of diabetes, immunology, neurology and oncology.

Publications :
• Development and use of a receptor antibody to characterize the interaction between somatostatin receptor sst1 and G proteins. Mol Pharmacol. 1995 Dec;48(6):1004-14
• Localization of the stomatostatin receptor sst2A in rat brain using a specific anti peptide antibody. J Neurosci. 1996 Jul 15;16(14):4468-78.
• Coupling specificity between somatostatin receptor sst2A and G proteins: Isolation of the receptor-G protein complex with a receptor antibody. Mol Endocrinol. 1997 May;11(5):527-37.
• Agonist induced desensitization, internalization and phosphorylation of the sst2A somatostatin receptor. J Biol Chem. 1997 May 23;272(21):13869-76.

UTHealth Ref. No.: 1994-0006
Inventors: Dr. Agnes Schonbrunn
Patent Status: issued U.S. Patent 5,998,154
License Available: world-wide; exclusive or non-exclusive