Anti-Sentrin (Sumo-1) Polyclonal Antibody
Background: Small Ubiquitin-like Modifier (SUMO) is a family
of proteins that modify other proteins by attaching and detaching covalently.
SUMO modification of proteins has many functions, including protein stability,
nuclear-cytosolic transport, and transcriptional regulation. Such fundamental
activities lead to potential market impact in a wide array of fields such as
oncology, immunology, and metabolics.
The Technology : Dr. Edward Yeh at the University of Texas
Health Science Center at Houston (UTHealth) has developed an anti-Sentrin
polyclonal antibody. This tool can be used to study cellular expression,
regulation, and interactions in the SUMO conjugation system..
Publications:
• Okura T, Gong L, Kamitani T, Wada T,
Okura I, Wei CF, Chang HM, Yeh ET. Protection against Fas/APO-1- and tumor
necrosis factor-mediated cell death by a novel protein, sentrin. J Immunol. 1996
Nov 15;157(10):4277-81.
• Kamitani T, Nguyen HP, Yeh ET. Preferential
modification of nuclear proteins by a novel ubiquitin-like molecule. J Biol
Chem. 1997 May 30;272(22):14001-4.
• Izumiya Y, Ellison TJ, Yeh ET, Jung
JU, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP represses
gene transcription via SUMO modification. J Virol. 2005
Aug;79(15):9912-25.
• Cheng J, Wang D, Wang Z, Yeh ET. SENP1 enhances
androgen receptor-dependent transcription through desumoylation of histone
deacetylase 1. Mol Cell Biol. 2004 Jul;24(13):6021-8.
• Gong L, Yeh
ET. Characterization of a family of nucleolar SUMO-specific proteases with
preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun
9;281(23):15869-77. Epub 2006 Apr 11.
• Bawa-Khalfe T, Cheng J, Wang Z, Yeh
E. Induction of the SUMO-specific protease 1 transcription by the androgen
receptor in prostate cancer cells. J Biol Chem. 2007 Dec
28;282(52):37341-9. Epub 2007 Oct 11
UTHealth Ref. No.:
1996-0013RMD
Inventors: Edward Yeh
License
Available: world-wide; non-exclusive