Anti Sentrin Antibody


Anti-Sentrin (Sumo-1) Polyclonal Antibody

Background: Small Ubiquitin-like Modifier (SUMO) is a family of proteins that modify other proteins by attaching and detaching covalently. SUMO modification of proteins has many functions, including protein stability, nuclear-cytosolic transport, and transcriptional regulation. Such fundamental activities lead to potential market impact in a wide array of fields such as oncology, immunology, and metabolics.

The Technology : Dr. Edward Yeh at the University of Texas Health Science Center at Houston (UTHealth) has developed an anti-Sentrin polyclonal antibody. This tool can be used to study cellular expression, regulation, and interactions in the SUMO conjugation system..

• Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, Chang HM, Yeh ET. Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin. J Immunol. 1996 Nov 15;157(10):4277-81.
• Kamitani T, Nguyen HP, Yeh ET. Preferential modification of nuclear proteins by a novel ubiquitin-like molecule. J Biol Chem. 1997 May 30;272(22):14001-4.
• Izumiya Y, Ellison TJ, Yeh ET, Jung JU, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol. 2005 Aug;79(15):9912-25.
• Cheng J, Wang D, Wang Z, Yeh ET. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol. 2004 Jul;24(13):6021-8.
• Gong L, Yeh ET. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun 9;281(23):15869-77. Epub 2006 Apr 11.
• Bawa-Khalfe T, Cheng J, Wang Z, Yeh E. Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. J Biol Chem. 2007 Dec 28;282(52):37341-9. Epub 2007 Oct 11

UTHealth Ref. No.: 1996-0013RMD
Inventors: Edward Yeh
License Available: world-wide; non-exclusive

Patent Information:

The preceding is intended to be a non-confidential and limited description of a novel technology created at the University of Texas Health Science Center at Houston (UTHealth). This promotional material is not comprehensive in scope and should not replace company’s diligence in a thorough evaluation of the technology. Please contact the Office of Technology Management for more information regarding this technology.
Research Materials
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Christine Weaver
Director, Licensing and New Venture Development
University of Texas Health Science Center At Houston
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