Anti-OPN Polyclonal Antisera


Anti-OPN Polyclonal Antisera

The Technology: Researchers at the University of Texas Health Science Center at Houston (UTHSC-H) have developed methods and compositions to analyze and study sialic rich proteins found in osteopontin (OPN), a type of mineralized tissue containing non-collagenous proteins. More specifically, Western immunoblots were performed with anti-OPN polyclonal antisera raised from rabbits. OPN has never been detected in dentin extracts by Western immunoblotting until now, making the antisera an excellent tool for further research into the formation of bone and dentin.


• Qin C, Brunn JC, Jones J, George A, Ramachandran A, Gorski JP, Butler WT. A comparative study of sialic acid-rich proteins in rat bone and dentin. Eur J Oral Sci. 2001 Apr;109(2):133-41.
• Razzouk S, Brunn JC, Qin C, Tye CE, Goldberg HA, Butler WT. Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion. Bone. 2002 Jan;30(1):40-7.
• Gericke A, Qin C, Spevak L, Fujimoto Y, Butler WT, Sørensen ES, Boskey AL. Importance of phosphorylation for osteopontin regulation of biomineralization. Calcif Tissue Int. 2005 Jul;77(1):45-54. Epub 2005 Jul 14.


UTHealth Ref. No.: 2006-0037 RMD
Inventors: Qin
License Available: worldwide; non-exclusive

Patent Information:

The preceding is intended to be a non-confidential and limited description of a novel technology created at the University of Texas Health Science Center at Houston (UTHealth). This promotional material is not comprehensive in scope and should not replace company’s diligence in a thorough evaluation of the technology. Please contact the Office of Technology Management for more information regarding this technology.
Research Materials
For Information, Contact:
Yu-Jane Wu
Senior Licensing Associate
University of Texas Health Science Center At Houston
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