Description:
Nilotinib (TasignaTM) is an off-patent, FDA-approved kinase inhibitor. Researchers at UTHealth have discovered it as a promising repurposed drug for muscle wasting treatment at a significantly lower than FDA-approved dose. At 500 nM in vitro, it abrogates muscle catabolism without suppressing myogenesis by selectively inhibiting p38β MAPK, and systemic administration of nilotinib at a low dose of 0.5 mg/kg/day alleviates muscle wasting and prolongs lifespan in tumor-bearing mice. The experimental results highlight the great potential of Nilotinib as a therapeutic for syndromes such as cancer-associated cachexia and sarcopenia.
Background
Cancer has been increasingly recognized as a systemic disease that causes disorders in multiple organs that are not resided by cancer per se. Cachexia, characterized by muscle wasting, is a metabolic syndrome seen in approximately 60% of cancer patients and the direct cause of ~1/3 of cancer-related deaths. Thus, cachexia is a major determinant for cancer patients’ survival. However, there is no established treatment for cancer cachexia due to the poor understanding of its etiology. The unmet medical need for treating cancer cachexia is substantial.
Discovery
Nilotinib (TasignaTM) an off patent, FDA-approved kinase inhibitor has been used by UTHealth investigators at a significantly lower than approved dose as a treatment for muscle wasting. This suggests great potential as a therapeutic for syndromes such as cancer-associated cachexia and sarcopenia.
At 500 nM in vitro, it abrogates muscle catabolism without suppressing myogenesis mediated by p38β MAPK, and systemic administration of nilotinib at a low dose of 0.5 mg/kg/day alleviates muscle wasting and prolongs lifespan in tumor-bearing mice.
Technology Highlights
• Nilotinib, an FDA-approved kinase inhibitor that preferentially binds p38β MAPK (Kd 32 nM) abrogates cancer-induced muscle catabolism at 500 nM in vitro:
• ~20-fold more potent than the p38α/β MAPK inhibitor SB202190
• without suppressing myogenesis mediated by p38a MAPK
• Systemic administration of nilotinib in vivo at a low dose of 0.5 mg/kg/day
alleviates muscle wasting and prolongs lifespan in tumor-bearing mice.
![](data:image/png;base64,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)
![](data:image/png;base64,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)
![](data:image/png;base64,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)
Potential Applications
• Cachexia induced by cancer, sepsis and other inflammatory diseases
• Sarcopeni
Intellectual Property Status
• US Patent filed: US17, 223,597
• Available for licensing
Stage of Development
Preclinical
Associated Publication
About the Principal Investigator
Yi-Ping Li, Ph.D., is a Professor in the Department of Integrative Biology and Pharmacology at McGovern Medical School at UTHealth, Houston Texas. His research interests focus on signaling mechanisms of striated muscle remodeling.
UTHealth Ref. No.: 2020-0026