Search Results - Therapeutics

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NOVEL COMPOUNDS AND METHODS OF USE FOR THE TREATMENT AND PREVENTION OF CANCER VIA INHIBITION OF THE K-RAS PATHWAY

Novel compounds and methods of use for the treatment and prevention of cancer via inhibition of the k-ras pathway Background: The Ras protein family members belong to a class of proteins called small GTPases and when activated by incoming signals, it subsequently switches on other genes involved in cell growth, differentiatio...

Published: Apr 2, 2013 | Inventor(s):

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Category(s): Therapeutics

Methods and composition for novel anti-cancer treatments

Background: The Wnt signaling pathway plays essential roles in development and is frequently hyperactivated in cancer cells as a driving mechanism. Nearly 90% of colon cancers, for examples are mutated in this pathway. However, direct targeting of this pathway for cancer drug discovery has been challenging due to receptor redundancy and compl...

Published: Mar 25, 2013 | Inventor(s):

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Category(s): Therapeutics, Diagnostics

Compositions and Methods for Regulation of Stem Cell Survival, Proliferation, and Differentiation

Background: Regenerative medicine is the process of using stem cells or related products to repair or repopulate organs or tissues damaged by a disease. Stem cell-based regenerative therapies may be used to heal or treat a wide range of conditions including cardiovascular disease, cancer, osteoporosis, Alzheimer’s disease, Parkinson’s disease...

Published: Jan 9, 2013 | Inventor(s):

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Category(s): Therapeutics

Preparation and Use of Alveoar Cells to Treat Lung Disorders

Background Alveolar type II (ATII) cells have numerous functions related to lung homeostatsis; these include (i) acting as progenitors for alveolar type I (ATI) cells, which is particularly important during re-epithelialization of the lung after injury; (ii) synthesis and secretion surfactant proteins, which reduces surface tension and helps p...

Published: Jul 23, 2012 | Inventor(s):

Keywords(s): Therapeutics

Category(s): Therapeutics

Modulation of Small Biomolecule Levels for the Treatment of Sickle Cell Disease

Market: Sickle-cell disease (SCD) (also known as sickle-cell anemia) is an inherited life-long blood disease that affects millions of people worldwide. In the United States alone, SCD affects nearly 90,000 – 100,000 Americans. SCD results from a mutation in hemoglobin which causes the red blood cells to acquire an unusual sickle shape that hin...

Published: Apr 23, 2012 | Inventor(s):

Keywords(s):

Category(s): Therapeutics

Treatment and Prevention of Vascular Disease with Hybrid Cyclooxygenase:Eicosanoid Proteins

Market: Some form of vascular disease effects one in four Americans, and costs for treatment reach into the billions. Prostanoids are an important, and emerging, therapeutic target in the campaign against vascular disease. Competitors and Current Problems: The prostanoid synthesis pathway is complicated, difficult to direct, and can have multi...