Search Results - Therapeutics

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Novel Fendiline Derivatives for the Treatment of KRAS Mutant Tumors
Novel Compounds and Methods of Use for the Treatment and Prevention of Cancer via Inhibition of the K-Ras Pathway Background: The Ras protein family members belong to a class of proteins called small GTPases and when activated by incoming signals, it subsequently switches on other genes involved in cell growth, differentiation, and survival. As a...
Published: 9/22/2020   |   Inventor(s):  
Keywords(s):  
Category(s): Oncology, Therapeutics
Method of Attenuation and Repair of Brain Lesions in Multiple Sclerosis Patients
BackgroundACZ is a reversible carbonic anhydrase enzyme inhibitor. This now generic medication has a good safety and tolerability profile, and is known to transiently enhance cerebral perfusion. Enhancing perfusion might improve tissue integrity within areas previously injured. Technology Overview- Patients tolerated doses of ACZ up to 4000 mg daily...
Published: 8/4/2020   |   Inventor(s): Jerry Wolinsky, John A Lincoln, Ponnada Narayana
Keywords(s):  
Category(s): Therapeutics
Method to Inhibit Muscle Wasting
METHOD TO INHIBIT MUSCLE WASTINGNilotinib (TasignaTM) an off patent, FDA-approved kinase inhibitor has been used by UTHealth investigators at a significantly lower than approved dose as a treatment for muscle wasting. This suggests great potential as a therapeutic for syndromes such as cancer-associated cachexia and sarcopenia.At 500 nM in vitro, it...
Published: 4/15/2020   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics
Monoclonal antibodies against human and mouse leptin for therapeutic and diagonostic use.
BackgroundLeptin is a hormone produced by adipocytes and is elevated in obesity. The congenital lack of leptin results in obesity and the metabolism field widely accepts the concept. Upon cloning of the leptin gene, the original hope was that leptin would act as a break for further food intake and a trigger to increase energy expenditure. The hope was...
Published: 3/5/2020   |   Inventor(s): Zhiqiang An, Philipp Scherer, Ningyan Zhang
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics, Metabolism
Formulation of HDACi Loaded ß-Cyclodextrin-poly (ß-amino ester) Nanoparticles
Researchers have developed a novel formulation strategy to encapsulate molecules, including but not limited to histone deacetylase inhibitor (HDACi) drugs in nanoparticle networks composed of beta-cyclodextrin-poly(beta-amino esters). Advantages of this system include high loading capacity, increased in vivo tolerability, sustained release, and improved...
Published: 1/15/2020   |   Inventor(s): Rachael Sirianni
Keywords(s):  
Category(s): Drug Delivery, Therapeutics, Oncology
Monoclonal antibodies against human endotrophin for therapeutic and diagonostic use.
BackgroundStudies have shown that endotrophin, the carboxy-terminal cleavage product of the COL6α3 chain, has potent effects on transformed mammary ductal epithelial cells in rodents. It is abundantly expressed in adipose tissue and is a chemoattractant for macrophages, exerts effects on endothelial cells and enhances the progression through epithelial-mesenchymal...
Published: 1/10/2020   |   Inventor(s): Zhiqiang An, Ningyan Zhang, Philipp Scherer
Keywords(s):  
Category(s): Biologics, Oncology, Therapeutics
HER3 specific monoclonal antibodies for diagnosis and therapeutic use
BackgroundHER-3 is a receptor in the tyrosine kinase family that is a key oncogenic protein in breast cancer as well as other cancers. HER-3 is centrally involved in signaling leading to tumor growth and has been implicated in resistance to cancer treatments, making it an attractive target for cancer therapies. Several drugs, including some in clinical...
Published: 1/8/2020   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Therapeutics, Diagnostics
Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payloads...
Published: 10/17/2019   |   Inventor(s): Kyoji Tsuchikama, Yasuaki Anami, Chisato Tsuchikama, Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Methods and composition for novel anti-cancer treatments
Background: The Wnt signaling pathway plays essential roles in development and is frequently hyperactivated in cancer cells as a driving mechanism. Nearly 90% of colon cancers, for examples are mutated in this pathway. However, direct targeting of this pathway for cancer drug discovery has been challenging due to receptor redundancy and complexity....
Published: 6/26/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics, Diagnostics
Methods of X-aptamer generation and compositions thereof
Aptamers are structurally distinct RNA and DNA oligonucleotides (ODNs) that can mimic protein-binding molecules and exhibit high (nM) binding affinity based on their unique secondary three-dimensional structure conformations and not by pair-wise nucleic acid binding. Aptamers can be selected via high-throughput in vitro methods to bind target molecules....
Published: 6/26/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics, Diagnostics
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