Search Results - Therapeutics

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Monoclonal antibodies against EGFL6 for diagnostic and cancer therapeutic use
EGFL6 is a member of the EGF repeat superfamily that is involved in wound healing. However, elevated EGFL6 has also been found in variety of cancer cell types, such as ovarian cancer and lung cancer. Studies herein demonstrate that inhibition of EGFL6 activity is effective for inhibiting cancer cell proliferation and angiogenesis in tumor tissues i...
Published: 9/6/2016   |   Inventor(s):  
Keywords(s):  
Category(s): Biologics, Therapeutics
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to tre...
Published: 7/13/2016   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Keywords(s):  
Category(s): Therapeutics, Research Materials
Connexin (Cx)43 Hemichannel-Binding Antibodies And Uses Thereof
Connexin hemichannels play important roles in the cell and tissue function, and abnormal function of connexin hemichannels may be involved various pathological conditions, such as cancer, neurological injury and osteoarthritis. There remains a need for additional therapies for treating pathological conditions associated with hemichannels activity (...
Published: 6/17/2016   |   Inventor(s):  
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Category(s): Biologics, Therapeutics
Chimeric and humanized antibodies against LILRBs for cancer treatment
UTHealth inventors have developed a number of anti-LILRB mAb, each of which efficiently block human acute myeloid leukemia (AML) development in various xenografted mouse models. Previous studies show that LILRBs are good targets of AML. These exciting results indicate that LILRBs support the activity of leukemia stem cells and leukemia 5 developmen...
Published: 6/8/2016   |   Inventor(s):  
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Category(s): Biologics, Therapeutics
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections Dr. Charles Darkoh has identified and developed novel compounds that may reduce or inhibit toxin production and toxin activity, which directly and selectively targets the cause of C. difficile-associated illness. Dr. Darkoh has further developed potential combinati...
Published: 1/28/2016   |   Inventor(s): Charles Darkoh
Keywords(s):  
Category(s): Diagnostics, Therapeutics
Supplementing culture media with prostaglandin or its analog to enhance the development of embryos
Abstract A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human blastocysts is enhanced...
Published: 11/5/2015   |   Inventor(s):  
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Category(s): Therapeutics
Agglomerated particles responding to hypoglycemia
Background: Diabetes is a disease caused by an insulin deficiency or a resistance to insulin in the body. Type I diabetes is an autoimmune disease that damages the beta cells of the islets of Langerhans in the pancreas, resulting in an inadequate amount of insulin in the body. Without insulin treatments, Type I diabetes is fatal. Type II diabetes ...
Published: 8/5/2015   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics
Phospholipid Associated 5-ASA for the Treatment of Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) which represents a spectrum of diseases of the lower GI tract, notably Ulcerative Colitis (UC) and Crohn’s Disease (CD), is one of the most common gastrointestinal (GI) afflictions in the United States and Europe. It is also noteworthy that the incidence of UC has increased 2-3 fold in China and other counties ...
Published: 9/15/2014   |   Inventor(s):  
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Category(s): Therapeutics
Antibiotic Microspheres For Treatment Of Infections And Osteomyelitis
More than 750,000 people in the United States have knees, hips, or shoulders replaced surgically each year. For about 30,000 of these patients the surgery results in osteomyelitis, a dangerous infection of the bone tissue. This infection results in repeat surgeries for repair, replacement, and sometimes even removal of the implant. To treat osteo...
Published: 3/20/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices, Therapeutics
Diagnostic and Method for Detection of Ankylosing Spondylitis
diagnostic and method for detection of aNKYLOSING SPONDYLITIS Background: Ankylosing spondylitis (AS) is one of the most common causes of inflammatory arthritis. AS is characterized by spinal and sacroiliac joint inflammation which causes pain and stiffness and eventually leads to bony ankylosis. Hip and peripheral joints ar...
Published: 6/3/2013   |   Inventor(s):  
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Category(s): Therapeutics
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