Search Results - Therapeutics

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Multistage Nanoparticle Drug Delivery Systems
The Market: The American Cancer Society estimates that in the United States alone, over 1,000,000 people are diagnosed with cancer. Many cancer deaths, specifically from cancers of the colon, breast, rectum, and uterine cervix cancers, could be significantly reduced with earlier detection and improved targeted delivery of chemotherapeutics. The Na...
Published: 5/23/2017   |   Inventor(s):  
Category(s): Therapeutics, Drug Delivery
One pot difunctionalization of hyaluronic acid with thiol and azide groups
Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cell...
Published: 4/14/2017   |   Inventor(s): Laura Smith Callahan, Hyun Ju Lim
Category(s): Drug Delivery, Research Materials, Therapeutics
Synthetic Peptide based Delivery System to Target Delivery of Antibacterial Agents (Targeting a Quorum Sensing System)
The emergence of drug-resistant pathogens is a global concern for human health, in the United States at least 2 million people become infected with antibiotic resistant bacteria and it leads to the death of at least 23,000 people per year. Exemplary bacteria are rapidly developing resistance against various antibiotics. Therefore, while continual e...
Published: 2/14/2017   |   Inventor(s):  
Category(s): Drug Delivery, Biologics, Therapeutics
Monoclonal antibodies against EGFL6 for diagnostic and cancer therapeutic use
EGFL6 is a member of the EGF repeat superfamily that is involved in wound healing. However, elevated EGFL6 has also been found in variety of cancer cell types, such as ovarian cancer and lung cancer. Studies demonstrate that inhibition of EGFL6 activity is effective for inhibiting cancer cell proliferation and angiogenesis in tumor tissues in anima...
Published: 9/6/2016   |   Inventor(s):  
Category(s): Biologics, Therapeutics
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to tre...
Published: 7/13/2016   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Category(s): Therapeutics, Research Materials
Connexin (Cx)43 Hemichannel-Binding Antibodies And Uses Thereof
Connexin hemichannels play important roles in the cell and tissue function, and abnormal function of connexin hemichannels may be involved various pathological conditions, such as cancer, neurological injury and osteoarthritis. There remains a need for additional therapies for treating pathological conditions associated with hemichannels activity (...
Published: 6/17/2016   |   Inventor(s):  
Category(s): Biologics, Therapeutics
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections Dr. Charles Darkoh has identified and developed novel compounds that may reduce or inhibit toxin production and toxin activity, which directly and selectively targets the cause of C. difficile-associated illness. Dr. Darkoh has further developed potential combinati...
Published: 1/28/2016   |   Inventor(s): Charles Darkoh
Category(s): Diagnostics, Therapeutics
Supplementing culture media with prostaglandin or its analog to enhance the development of embryos
Abstract A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human blastocysts is enhanced...
Published: 11/5/2015   |   Inventor(s):  
Category(s): Therapeutics
Agglomerated particles responding to hypoglycemia
Background: Diabetes is a disease caused by an insulin deficiency or a resistance to insulin in the body. Type I diabetes is an autoimmune disease that damages the beta cells of the islets of Langerhans in the pancreas, resulting in an inadequate amount of insulin in the body. Without insulin treatments, Type I diabetes is fatal. Type II diabetes ...
Published: 8/5/2015   |   Inventor(s):  
Category(s): Therapeutics
Phospholipid Associated 5-ASA for the Treatment of Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) which represents a spectrum of diseases of the lower GI tract, notably Ulcerative Colitis (UC) and Crohn’s Disease (CD), is one of the most common gastrointestinal (GI) afflictions in the United States and Europe. It is also noteworthy that the incidence of UC has increased 2-3 fold in China and other counties ...
Published: 9/15/2014   |   Inventor(s):  
Category(s): Therapeutics
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