Search Results - Therapeutics

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Targeted Tocolytic Liposomes for Preterm Labor
Background:Every year, more than 1 in 10 babies are born prematurely, before 37 weeks of pregnancy. Complications resulting from preterm birth is the leading cause of death in children under 5 years of age, and the rate of preterm birth has increased steadily in the past decades. Preterm birth due to preterm labor continues to be a challenging con...
Published: 1/31/2018   |   Inventor(s): Jerrie S Refuerzo, Monica Longo, Biana Godin-Vilentchouk
Category(s): Therapeutics
Caffeinol: Composition and Method for Treatment of Cerebral Ischemia
Caffeinol: Composition and Method for Treatment of Cerebral IschemiaStroke & Current Treatment Approximately 800,000 strokes occur in the United States each year costing the U.S. an estimated 34 billion dollars per year. Stroke is the 4th leading cause of death in the U.S., leading cause of disability in the elderly, and the 2nd leading cause o...
Published: 1/26/2018   |   Inventor(s): James Grotta, Jaroslaw Aronowski
Category(s): Therapeutics
Recombinant Proteins for the Treatment of Intracerebral Hemorrhage
BackgroundIntracerebral hemorrhage (ICH) is a devastating form of stroke, with the highest mortality of all stroke subtypes. Rapid accumulation of blood and immune cells result in oxidative stress, inflammation, and the accumulation of toxic hemolytic products at the site of the stroke, leading to significant injury to the brain. There are no ef...
Published: 11/20/2017   |   Inventor(s):  
Category(s): Therapeutics, Biologics
New approach to isolation and improved design of adipose cell-targeted cytotoxic peptides
METHODS AND COMPOSITIONS FOR TARGETING ADIPOSE TISSUE IN MAMMALSBackground and Market: Obesity, caused by overgrowth of white adipose (fat) tissue, is a risk and complicating factor for cardiovascular diseases, Type 2 diabetes, certain types of cancer, and may other pathologies. No effective pharmaceutical treatments against obesity are currently a...
Published: 10/12/2017   |   Inventor(s):  
Category(s): Therapeutics
Multistage Nanoparticle Drug Delivery Systems
The Market: The American Cancer Society estimates that in the United States alone, over 1,000,000 people are diagnosed with cancer. Many cancer deaths, specifically from cancers of the colon, breast, rectum, and uterine cervix cancers, could be significantly reduced with earlier detection and improved targeted delivery of chemotherapeutics. The Na...
Published: 5/23/2017   |   Inventor(s):  
Category(s): Therapeutics, Drug Delivery
One pot difunctionalization of hyaluronic acid with thiol and azide groups
Hyaluronic Acid (HA) is a polysaccharide that is expressed in the extracellular matrix (ECM) of all vertebrate tissues, contributing to the development of cells in tissue. HA based hydrogels are useful tools in tissue engineering as the HA can be modified with bioactive peptides to facilitate the growth, differentiation and attachment of stem cell...
Published: 4/14/2017   |   Inventor(s): Laura Smith Callahan, Hyun Ju Lim
Category(s): Drug Delivery, Research Materials, Therapeutics
Synthetic Peptide based Delivery System to Target Delivery of Antibacterial Agents (Targeting a Quorum Sensing System)
The emergence of drug-resistant pathogens is a global concern for human health, in the United States at least 2 million people become infected with antibiotic resistant bacteria and it leads to the death of at least 23,000 people per year. Exemplary bacteria are rapidly developing resistance against various antibiotics. Therefore, while continual e...
Published: 2/14/2017   |   Inventor(s):  
Category(s): Drug Delivery, Biologics, Therapeutics
Monoclonal antibodies against EGFL6 for diagnostic and cancer therapeutic use
EGFL6 is a member of the EGF repeat superfamily that is involved in wound healing. However, elevated EGFL6 has also been found in variety of cancer cell types, such as ovarian cancer and lung cancer. Studies demonstrate that inhibition of EGFL6 activity is effective for inhibiting cancer cell proliferation and angiogenesis in tumor tissues in anima...
Published: 9/6/2016   |   Inventor(s):  
Category(s): Biologics, Therapeutics
Novel Channelrhodopsins for Inhibition of Neuronal Activity
Optogenetics is rapidly evolving field that provides the ability to control neurons using light-sensitive proteins called channelrhodopsins (ChRs). When genetically expressed in neurons, ChRs have the ability to selectively manipulate neuronal activity in a light-dependent manner. Gene-therapy using ChRs has the exciting potential to be used to tre...
Published: 7/13/2016   |   Inventor(s): John Spudich, Elena G Govorunova, Oleg A Sineshchekov
Category(s): Therapeutics, Research Materials
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections
Novel Compounds for the Prevention and Treatment of Clostridium difficile Infections Dr. Charles Darkoh has identified and developed novel compounds that may reduce or inhibit toxin production and toxin activity, which directly and selectively targets the cause of C. difficile-associated illness. Dr. Darkoh has further developed potential combinati...
Published: 1/28/2016   |   Inventor(s): Charles Darkoh
Category(s): Diagnostics, Therapeutics
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