Search Results - Therapeutics

33 Results Sort By:
Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payl...
Published: 10/17/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Methods and composition for novel anti-cancer treatments
Background: The Wnt signaling pathway plays essential roles in development and is frequently hyperactivated in cancer cells as a driving mechanism. Nearly 90% of colon cancers, for examples are mutated in this pathway. However, direct targeting of this pathway for cancer drug discovery has been challenging due to receptor redundancy and compl...
Published: 6/26/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics, Diagnostics
Methods of X-aptamer generation and compositions thereof
Aptamers are structurally distinct RNA and DNA oligonucleotides (ODNs) that can mimic protein-binding molecules and exhibit high (nM) binding affinity based on their unique secondary three-dimensional structure conformations and not by pair-wise nucleic acid binding. Aptamers can be selected via high-throughput in vitro methods to bind target molec...
Published: 6/26/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics, Diagnostics
Salivary Proline Rich Peptide Decreases Growth of Cancer Cells
Background:Carcinoma of the breast is the second most common type of cancer among women and despite improved early detection, diagnosis and aggressive treatment approaches, consisting of surgery, radiotherapy and/or chemotherapy, carcinoma of the breast is still a great threat to human life. Currently, there is an incomplete knowledge of the molecu...
Published: 8/24/2018   |   Inventor(s):  
Keywords(s):  
Category(s): Oncology, Therapeutics, Biologics
Discovery of Allosteric Non-Covalent KRAS Inhibitors
Activating mutations of KRAS are known to occur in about 25% of all human cancers. Currently, there are no drugs that can directly act on mutated KRAS to stop its cancer causing activities. As a result, KRAS-related cancers, which include some of the deadliest, such as pancreatic cancer, remain untreatable. Finding a direct inhibitor of KRAS remain...
Published: 8/13/2018   |   Inventor(s):  
Keywords(s):  
Category(s): Oncology, Therapeutics, Research Materials
Human Amniotic Fluid Supernatant as a Therapeutic Agent for Hyperproliferative and Inflammatory Skin Conditions.
Keratinocytes are a major cell type in the epidermis. However, keratin proliferation and dysregulation can lead to many keratin associated diseases or disorders, including hyperproliferative skin disorders such as psoriasis, eczema, and keratosis, scaring or suboptimal wound healing. Faculty members at the University of Texas Health Science Center ...
Published: 8/13/2018   |   Inventor(s):  
Keywords(s):  
Category(s): Biologics, Therapeutics
Targeted Tocolytic Liposomes for Preterm Labor
Background:Every year, more than 1 in 10 babies are born prematurely, before 37 weeks of pregnancy. Complications resulting from preterm birth is the leading cause of death in children under 5 years of age, and the rate of preterm birth has increased steadily in the past decades. Preterm birth due to preterm labor continues to be a challenging con...
Published: 1/31/2018   |   Inventor(s): Jerrie S Refuerzo, Monica Longo, Biana Godin-Vilentchouk
Keywords(s):  
Category(s): Therapeutics
Caffeinol: Composition and Method for Treatment of Cerebral Ischemia
Caffeinol: Composition and Method for Treatment of Cerebral IschemiaStroke & Current Treatment Approximately 800,000 strokes occur in the United States each year costing the U.S. an estimated 34 billion dollars per year. Stroke is the 4th leading cause of death in the U.S., leading cause of disability in the elderly, and the 2nd leading cause o...
Published: 1/26/2018   |   Inventor(s): James Grotta, Jaroslaw Aronowski
Keywords(s):  
Category(s): Therapeutics
Recombinant Proteins for the Treatment of Intracerebral Hemorrhage
BackgroundIntracerebral hemorrhage (ICH) is a devastating form of stroke, with the highest mortality of all stroke subtypes. Rapid accumulation of blood and immune cells result in oxidative stress, inflammation, and the accumulation of toxic hemolytic products at the site of the stroke, leading to significant injury to the brain. There are no ef...
Published: 11/20/2017   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics, Biologics
New approach to isolation and improved design of adipose cell-targeted cytotoxic peptides
METHODS AND COMPOSITIONS FOR TARGETING ADIPOSE TISSUE IN MAMMALSBackground and Market: Obesity, caused by overgrowth of white adipose (fat) tissue, is a risk and complicating factor for cardiovascular diseases, Type 2 diabetes, certain types of cancer, and may other pathologies. No effective pharmaceutical treatments against obesity are currently a...
Published: 10/12/2017   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutics
1 2 3 4 
© 2019. All Rights Reserved. Powered by Inteum