Search Results - Neurology%2fNeurosurgery

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S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use
Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Oncology, Therapeutics
LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An, Ningyan Zhang
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics
Novel Channelrhodopsins for Optogenetics Gene Therapy (CCRs and KCRs)
When expressed in targeted neurons, light-sensitive channelrhodopsin proteins (ChRs) have the ability to selectively manipulate neuronal activity in a light-dependent manner. Kalium (potassium)-conducting channelrhodopsins (KCRs) have the potential for optogenetic applications and as therapeutic agents for electrically active cell mediated disorders,...
Published: 10/21/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Research Materials, Therapeutics, Neurology/Neurosurgery
Monoclonal Antibodies Binding to Transferrin Receptor (TfR) for Therapeutic Protein Delivery across Blood-Brain Barrier
Blood-brain barrier (BBB) limits brain entry and is one of the major hurdles in developing antibody and protein-based therapeutics for central nervous system (CNS) diseases. UTHealth researchers identified and engineered monoclonal antibodies binding to transferrin receptor (TfR) but not affecting transferrin (Tf) binding to TfR. An engineered monovalent...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An
Keywords(s):  
Category(s): Drug Delivery, Therapeutics, Neurology/Neurosurgery, Oncology, Biologics
TREM2 Monoclonal Antibody for Therapeutic and Diagnostic Use
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. Previous studies in rodent models of AD have shown that mice with increased TREM2 expression have reduced amyloid pathology. UTHealth inventors created and...
Published: 10/21/2024   |   Inventor(s): Zhiqiang An
Keywords(s):  
Category(s): Therapeutics, Diagnostics, Biologics, Neurology/Neurosurgery
Identifying and characterizing genes whose perturbation leads to intracranial aneurysms (IA) and/or vascular endothelial cell dysfunction
The proposed invention involves identification and characterization of molecular targets for treating intracranial aneurysms. A focus is endothelial podosomes regulated by the transmembrane receptor protein THSD1. THSD1 also regulates autophagy processes that contribute to aneurysm formation as well as positively regulates TGFβ signaling, which...
Published: 10/21/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Neurology/Neurosurgery, Therapeutics, Diagnostics
Directional and Scalable (DISC) Electrode Array
­Overview. A directional and scalable (DISC) electrode array has been developed and tested to provide improved performance while overcoming limitations seen in conventional neural sensors. The array design proposed here is an improvement on the state-of-the-art electroencephalogram (sEEG) by enabling the recording of spatially distinct local field...
Published: 10/21/2024   |   Inventor(s): John Seymour, Nitin Tandon
Keywords(s):  
Category(s): Medical Devices, Neurology/Neurosurgery, Diagnostics
Systems and methods for network based neurostimulation of cognitive processes
Cognitive processes are brain operations that allow us to perform complex functions that are the very essence of being human—examples include but are not limited to memory, language, control over emotions, resolving conflicting information, reading, making decisions, puzzle solving etc. This invention describes a method and a system that utilizes...
Published: 10/21/2024   |   Inventor(s): Nitin Tandon
Keywords(s):  
Category(s): Medical Devices, Neurology/Neurosurgery
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