Search Results - Oncology

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Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payl...
Published: 10/17/2019   |   Inventor(s):  
Keywords(s):  
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Monoclonal Antibodies targeting EpCAM
AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection v...
Published: 10/17/2019   |   Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia
Keywords(s):  
Category(s): Biologics, Research Materials, Oncology, Diagnostics
Salivary Proline Rich Peptide Decreases Growth of Cancer Cells
Background:Carcinoma of the breast is the second most common type of cancer among women and despite improved early detection, diagnosis and aggressive treatment approaches, consisting of surgery, radiotherapy and/or chemotherapy, carcinoma of the breast is still a great threat to human life. Currently, there is an incomplete knowledge of the molecu...
Published: 8/24/2018   |   Inventor(s):  
Keywords(s):  
Category(s): Oncology, Therapeutics, Biologics
Discovery of Allosteric Non-Covalent KRAS Inhibitors
Activating mutations of KRAS are known to occur in about 25% of all human cancers. Currently, there are no drugs that can directly act on mutated KRAS to stop its cancer causing activities. As a result, KRAS-related cancers, which include some of the deadliest, such as pancreatic cancer, remain untreatable. Finding a direct inhibitor of KRAS remain...
Published: 8/13/2018   |   Inventor(s):  
Keywords(s):  
Category(s): Oncology, Therapeutics, Research Materials
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