Search Results - Biologics

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Monoclonal antibodies against human endotrophin for therapeutic and diagnostic use.

Background Studies have shown that endotrophin, the carboxy-terminal cleavage product of the COL6α3 chain, has potent effects on transformed mammary ductal epithelial cells in rodents. It is abundantly expressed in adipose tissue and is a chemoattractant for macrophages, exerts effects on endothelial cells and enhances the progression through...

Published: 2/8/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Philipp Scherer

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

EGFL6 Specific Monoclonal Antibodies for Cancer Diagnostic and Therapeutic Use

Human epidermal growth factor (EGF)-like domain multiple 6 (EGFL6) was discovered in tumors and fetal tissues. Upregulated expression of EGFL6 was found in a variety of cancer cell types, such as ovarian cancer and lung cancer. Unlike VEGF, which was expressed in ovarian cancer tissues and in healing wounds, EGFL6 was expressed mainly in tumor-associated...

Published: 12/19/2023 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Biologics, Therapeutics

Synthetic Antifungal Peptides

Novel antifungal compositions that inhibit fungal growth which have both medical and non-medical utility and applications Inventors at the University of Texas Health Science Center at Houston have developed a series of novel peptide compounds to inhibit fungal growth. The peptides are based on the bacteriocin EntV, which is secreted by Enterococcus...

Published: 2/8/2024 | Inventor(s): Danielle Garsin, Michael Lorenz

Keywords(s):

Category(s): Biologics, Therapeutics

LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 8/15/2023 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

Mutants and Drug Conjugates of R-Spondin Polypeptides for Cancer Therapy

R-spondins (RSPOs) are secreted proteins with critical roles in cancer development through binding to LGRs and RNF43/ZNRF3 and potentiating Wnt signaling. Various RSPO mutants were discovered that bind to LGRs but no longer function in Wnt signaling. Fc fusion protein of the RSPO mutants, so called RSPO peptibodies, were conjugated with cytotoxic...

Published: 8/15/2023 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Novel Oncolytic Herpes Simplex Virus (oHSV) for Cancer Treatment

Researchers from UTHealth have developed a novel oncolytic viral therapy, oHSV-shPKR, which can inhibit tumor cells’ antiviral PKR activity, and increase oncolytic virus infection and replication in both oncolytic viral-resistant and sensitive cancer cells. This novel oHSV-shPKR therapy can significantly increase the anti-tumor immune response...

Published: 8/15/2023 | Inventor(s): Balveen Kaur, BangXing Hong

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Monoclonal Antibodies Against Oncostatin M Receptor (OSMR) for Therapeutic and Diagnostic Use

Researchers from UTHealth and The Medical College of Wisconsin have collaborated to reveal the role of OSMR in promoting ovarian cancer cell proliferation and metastasis through activation of STAT3 signaling, as well as illuminated the preclinical efficacy of antibody-based OSMR targeting for ovarian cancer treatment. More particularly, researchers...

Published: 9/27/2023 | Inventor(s): Zhiqiang An

Keywords(s):

Category(s): Diagnostics, Therapeutics, Biologics, Oncology

Monoclonal Antibodies Against Chitinase 3-like-1 (Chi3l1) for Therapeutic and Diagnostic Use

Researchers at UTHealth have unveiled a critical role of Chi3l1 in hepatic platelet recruitment during acetaminophen (APAP)-induced liver injury (AILI) using murine models of AILI and concanavalin A (Con A)-induced hepatitis. Significantly, they have developed anti-Chi3l1 monoclonal antibodies and demonstrated the feasibility of targeting CHI3L1...

Published: 8/15/2023 | Inventor(s): Zhiqiang An, Changqing (Cynthia) Ju

Keywords(s):

Category(s): Biologics, Therapeutics, Oncology

Monoclonal antibodies against human and mouse leptin for therapeutic and diagnostic use.

BackgroundLeptin is a hormone produced by adipocytes and is elevated in obesity. The congenital lack of leptin results in obesity and the metabolism field widely accepts the concept. Upon cloning of the leptin gene, the original hope was that leptin would act as a break for further food intake and a trigger to increase energy expenditure. The hope was...

Published: 2/8/2024 | Inventor(s): Zhiqiang An, Philipp Scherer, Ningyan Zhang

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Metabolism

Monoclonal Antibodies targeting EpCAM

AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via...

Published: 8/15/2023 | Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia

Keywords(s):

Category(s): Biologics, Research Materials, Oncology, Diagnostics

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