Search Results - Biologics

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Improved Antibody-Drug Conjugate Linker Compositions and Methods of Use
Faculty members at the University of Texas Health Science Center at Houston have developed a novel chemical linker for constructing antibody-drug conjugates (ADCs). While traditional ADC linkers can only load a single payload molecule, the developed linker has the ability to load two identical or different drug payloads. Doubling the number of payl...
Published: 10/17/2019   |   Inventor(s):  
Category(s): Research Materials, Oncology, Drug Delivery, Therapeutics, Biologics
Monoclonal Antibodies targeting EpCAM
AbstractEmbodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection v...
Published: 10/17/2019   |   Inventor(s): Barrett Harvey, Eva Sevick, Kenneth Pinkston, Ali Azhdarinia
Category(s): Biologics, Research Materials, Oncology, Diagnostics
Salivary Proline Rich Peptide Decreases Growth of Cancer Cells
Background:Carcinoma of the breast is the second most common type of cancer among women and despite improved early detection, diagnosis and aggressive treatment approaches, consisting of surgery, radiotherapy and/or chemotherapy, carcinoma of the breast is still a great threat to human life. Currently, there is an incomplete knowledge of the molecu...
Published: 8/24/2018   |   Inventor(s):  
Category(s): Oncology, Therapeutics, Biologics
Human Amniotic Fluid Supernatant as a Therapeutic Agent for Hyperproliferative and Inflammatory Skin Conditions.
Keratinocytes are a major cell type in the epidermis. However, keratin proliferation and dysregulation can lead to many keratin associated diseases or disorders, including hyperproliferative skin disorders such as psoriasis, eczema, and keratosis, scaring or suboptimal wound healing. Faculty members at the University of Texas Health Science Center ...
Published: 8/13/2018   |   Inventor(s):  
Category(s): Biologics, Therapeutics
Recombinant Proteins for the Treatment of Intracerebral Hemorrhage
BackgroundIntracerebral hemorrhage (ICH) is a devastating form of stroke, with the highest mortality of all stroke subtypes. Rapid accumulation of blood and immune cells result in oxidative stress, inflammation, and the accumulation of toxic hemolytic products at the site of the stroke, leading to significant injury to the brain. There are no ef...
Published: 11/20/2017   |   Inventor(s):  
Category(s): Therapeutics, Biologics
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