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LGR4 Specific Monoclonal Antibodies and Their Use

Researchers at UTHealth have isolated and characterized monoclonal antibodies as well as antibody fragments that specifically binding to LGR4, a 7TM receptor that is highly expressed in major types of solid tumors, including but not limited to colorectal cancer, non-small cell lung cancer, and ovarian cancer. These LGR4 specific monoclonal antibodies...

Published: 10/21/2024 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics, Diagnostics, Research Materials

R-Spondin Polypeptides and Drug Conjugates for Cancer Treatment

R-spondins (RSPOs) are secreted proteins with critical roles in cancer development through binding to LGR4/5/6 and RNF43/ZNRF3 and potentiating Wnt signaling. UTHealth pioneering scientist engineered and fused an immunoglobin Fc domain to the mutated RSPOs (RSPO peptibodies). RSPO peptibodies can binds to LGR4/5/6 with high affinity but exhibit reduced...

Published: 10/21/2024 | Inventor(s): Qingyun (Jim) Liu

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics